Toxicologists & environmental researchers

Toxicological and environmental respiratory research was central to the development of our flagship technology PreciseInhale, and it remains so. PreciseInhale plays a key role in research into environmental respiratory pollutants, delivering major quality and cost benefits to governments, environmental agencies and research institutions worldwide.


Major cost savings in test substances

Scarcity of material and the need for respirable aerosol is an acute problem in the study of toxic airborne particles. Whether collected from the environment or manufactured in a lab, study materials are nearly always expensive. Even with industrial granular materials, selecting the minuscule fraction that is actually respirable is highly costly. PreciseInhale produces realistic aerosol exposures from minute amounts of collected / available study materials. The system typically uses between 50 – 100 mg of test substance for a full PK study, delivering accurate and detailed data exceptionally cost-effectively.

Experience and expertise

Toxicological and environmental research is in the DNA of our technology. Our paradigm-shifting inhalation R&D platform was originally developed as part of founder, Dr Per Gerde’s, research into radioactive diesel dust dosimetry in the lungs, at the elite Lovelace Respiratory Research Institute in the US. With our experience of risk assessment of carcinogenic substances, for toxicologist and environmental researchers, working with ISAB means working with seasoned experts who know their issues.

XposeALI: 3D in vitro cell exposure module

XposeALI, Inhalation Sciences’ patented in vitro cell exposure module delivers exceptional data on the cellular effects of airborne particles. The novel exposure system for airlifted cell cultures also has a dynamic perfusion system that better resembles the physiology of the living lung than conventional static systems.

 

Lena Palmberg, Associate Professor, lung and airway research Karolinska Institutet, institute of environmental medicine, Sweden:
“Cost-effective and very precise, Inhalation Sciences’ in vitro cell exposure system combines aerosol exposure of a unique 3D-model with primary human bronchial epithelial cells cultured in an air / liquid interface. It gives toxicologists and environmental researchers precise results that closely mirror in vivo.”

3R regulatory requirements met

The 3R era is with us (replacing, refining and reducing the number of animals in research.) Funding of 3R research is increasing significantly, and is a major opportunity for toxicologists and environmental researchers. PreciseInhale’s two in vitro modules replace animal testing; allowing researchers to both meet 3R requirements and achieve world-class data. The two in vitro models are: DissolvIt, our system for the simulation, dissolution and absorption of soluble particles in the air/blood barrier of the conduction airways, and the exposures of airlifted respiratory epithelial cells (ALI) to respirable aerosols. The models allow for cross-validating data across different exposure models. PreciseInhale’s unique one-animal-at-a-time reduces drastically the number of animals needed for inhalation research, and the standard deviation of results.